Description

Fmoc-3,5-Dimethyl-L-Phenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to introduce sterically hindered, hydrophobic side chains into peptide sequences, which is critical for modulating peptide stability, bioavailability, and receptor binding affinity. It is a vital building block for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require high-purity intermediates for creating novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptide chains.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Peptidomimetic Design: Incorporates a bulky, hydrophobic dimethylphenyl side chain to enhance metabolic stability and membrane permeability of peptide leads.
• Bioconjugation & Labeling: Serves as a precursor for creating modified peptides with specific tags or functional groups for diagnostic or targeting applications.
• Chemical Biology Probes: Utilized to synthesize peptides for studying protein-protein interactions and enzyme mechanisms.
• Material Science: A building block for constructing peptide-based biomaterials, hydrogels, and surface coatings with tailored properties.

Basic Information

Product Name	Fmoc-3,5-Dimethyl-L-Phenylalanine
CAS No.	1270295-34-5
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-3,5-Dimethyl-L-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,5-dimethyl-L-phenylalanine; Fmoc-Dmp-OH; Fmoc-3,5-diMe-L-Phe; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(3,5-dimethylphenyl)propanoic acid; N-α-Fmoc-3,5-dimethyl-L-phenylalanine; Fmoc-L-3,5-dimethylphenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-3,5-Dimethyl-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.