Description

Cbz-2,6-Dimethyl-L-Phenylalanine is a protected, non-natural amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex peptides and peptidomimetics, offering enhanced steric and electronic properties compared to its parent amino acid. It is primarily utilized by pharmaceutical research and development teams, as well as fine chemical manufacturers, for applications in drug discovery, particularly in the development of protease inhibitors and other bioactive molecules. Its high purity and defined stereochemistry are essential for ensuring the efficacy and reproducibility of downstream synthetic processes.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and receptor antagonists.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce sterically hindered, non-proteinogenic amino acid residues into peptide chains.
• Drug Discovery & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to modulate the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Bioconjugation & Probe Development: Acts as a modified amino acid for creating labeled peptides or affinity probes used in biochemical assays.
• Fine Chemical Synthesis: Serves as a versatile building block for the preparation of specialized catalysts, ligands, and other high-value organic molecules.

Basic Information

Product Name	Cbz-2,6-Dimethyl-L-Phenylalanine
CAS No.	1270294-57-9
Molecular Formula	C19H21NO4
Molecular Weight	327.38 g/mol
Synonyms	N-Carbobenzoxy-2,6-dimethyl-L-phenylalanine; (2S)-3-(2,6-Dimethylphenyl)-2-{[(benzyloxy)carbonyl]amino}propanoic acid; Z-2,6-Dimethyl-L-Phe-OH; Cbz-2,6-Dimethyl-L-Phe; Nα-Cbz-2,6-Dimethyl-L-phenylalanine; Benzyl N-[(1S)-1-carboxy-2-(2,6-dimethylphenyl)ethyl]carbamate; N-Cbz-2,6-Dimethylphenylalanine
EINECS	Contact for details

Quality Control

Our Cbz-2,6-Dimethyl-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and comprehensive impurity profiling, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.