Description

Cbz-3,4-Dimethy-L-Phenylalanine is a protected amino acid derivative, specifically an N-Carbobenzyloxy (Cbz) protected form of a modified L-phenylalanine. This compound is a critical building block in peptide synthesis and medicinal chemistry, where it serves to introduce a sterically hindered, hydrophobic side chain while protecting the amine functionality during coupling reactions. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for developing novel therapeutic peptides, peptidomimetics, and as a chiral synthon in asymmetric synthesis.

Application

• Peptide Synthesis: As a key protected amino acid intermediate for the solid-phase and solution-phase synthesis of complex peptides.
• Pharmaceutical Intermediates: Used in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Medicinal Chemistry: Serves as a versatile building block for creating compound libraries and exploring structure-activity relationships (SAR).
• Bioconjugation: Employed in the design and synthesis of peptide-based probes, drug conjugates, and biomaterials.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material for the preparation of enantiomerically pure compounds.
• Academic & Industrial Research: A valuable reagent for biochemical and chemical research in universities and corporate R&D laboratories.

Basic Information

Product Name	Cbz-3,4-Dimethy-L-Phenylalanine
CAS No.	1270290-55-5
Molecular Formula	C19H21NO4
Molecular Weight	327.38 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-3,4-dimethyl-L-phenylalanine; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-(3,4-dimethylphenyl)propanoic acid; Z-3,4-Dimethyl-L-Phenylalanine; Cbz-3,4-Dimethyl-L-Phe-OH; N-Cbz-3,4-Dimethyl-L-phenylalanine; Nα-Carbobenzyloxy-3,4-dimethyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Cbz-3,4-Dimethy-L-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and synthesis applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.