Description

5-Bromo-2-Fluoro-4-Methylbenzonitrile is a high-purity, multi-functional halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring bromine, fluorine, and nitrile substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the halogen and nitrile groups contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its ability to modify molecular polarity and conjugation.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to create complex biaryl and conjugated systems for material science applications.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and constructing molecular libraries for screening.

Basic Information

Item	Detail
Product Name	5-Bromo-2-Fluoro-4-Methylbenzonitrile
CAS No.	1269493-45-9
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	5-Bromo-2-fluoro-4-methylbenzonitrile; 2-Fluoro-4-methyl-5-bromobenzonitrile; 4-Bromo-2-fluoro-5-cyanotoluene; Benzonitrile, 5-bromo-2-fluoro-4-methyl-; 1269493-45-9; 5-Br-2-F-4-Me-C6H2CN
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Fluoro-4-Methylbenzonitrile is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.