Description

n-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propane-1-Sulfonamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group. This compound is critically important as a key building block in modern medicinal chemistry, specifically for Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex biaryl structures. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially those containing fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile boron-containing coupling partner for constructing carbon-carbon bonds between aromatic rings under mild conditions.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• API Development: Integral to process chemistry for scaling up the production of target molecules during clinical development phases.
• Chemical Biology Probes: Can be utilized to create labeled molecules for studying biological pathways and target engagement.
• Agrochemical Research: Potential application in the synthesis of new active ingredients for crop protection.

Basic Information

Product Name	n-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propane-1-Sulfonamide
CAS No.	1269233-76-2
Molecular Formula	C₁₅H₂₃BFNO₄S
Molecular Weight	355.22 g/mol
Synonyms	2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(propylsulfonyl)aniline; 1-Propanesulfonamide, N-[2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 1269233-76-2; 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl Propyl Sulfonamide; Boronic acid, B-[2-fluoro-3-[[(propylsulfonyl)amino]phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Every batch of our n-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propane-1-Sulfonamide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.