Description

(3-Amino-5-(Difluoromethoxy)Phenyl)Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters because its protected boronic acid group and unique difluoromethoxy-substituted aromatic amine structure enable efficient, selective cross-coupling reactions, particularly in complex molecule assembly. It is primarily needed by pharmaceutical R&D and agrochemical manufacturers for constructing novel active ingredients, as well as by advanced material scientists developing organic electronic components.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in next-generation herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or building block for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Chemical Biology & Probe Development: Employed in the synthesis of bioconjugates and molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring advanced boronic ester chemistry.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis studies within university and corporate laboratories.

Basic Information

Product Name	(3-Amino-5-(Difluoromethoxy)Phenyl)Boronic Acid Pinacol Ester
CAS No.	1269233-12-6
Molecular Formula	C₁₃H₁₈BF₂NO₃
Molecular Weight	285.10 g/mol
Synonyms	5-(Difluoromethoxy)-3-aminophenylboronic acid pinacol ester; 3-Amino-5-(difluoromethoxy)benzeneboronic acid pinacol ester; (3-Amino-5-(difluoromethoxy)phenyl)boronic acid pinacol ester; 2-(3-Amino-5-(difluoromethoxy)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; B-[3-Amino-5-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1269233-12-6; Boronic acid, B-[3-amino-5-(difluoromethoxy)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (3-Amino-5-(Difluoromethoxy)Phenyl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.