Description

3-(Trifluoromethyl)Oxolan-3-Amine is a high-value, fluorinated heterocyclic amine building block. This compound is significant for its unique structural motif combining an oxolane (tetrahydrofuran) ring with a reactive amine group and a trifluoromethyl substituent, offering distinct electronic and steric properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where the introduction of fluorine atoms can dramatically alter a molecule's metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Building Block: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, coatings, and liquid crystals with tailored surface properties.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution in heterocyclic systems and for developing new fluorination methodologies.
• Ligand Synthesis: Utilized in the preparation of novel chiral or achiral ligands for catalysis in asymmetric synthesis.

Basic Information

Product Name	3-(Trifluoromethyl)Oxolan-3-Amine
CAS No.	1269152-31-9
Molecular Formula	C5H8F3NO
Molecular Weight	155.12 g/mol
Synonyms	3-(Trifluoromethyl)tetrahydrofuran-3-amine; 3-Amino-3-(trifluoromethyl)oxolane; 3-Amino-3-(trifluoromethyl)tetrahydrofuran; 3-Trifluoromethyl-3-aminotetrahydrofuran; 3-TFMOA; Oxolan-3-amine, 3-(trifluoromethyl)-; 3-(Trifluoromethyl)-3-aminotetrahydrofuran
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Oxolan-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This amine is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.