Description

n-Boc-1-Ethynylcyclobutanamine is a high-purity, protected amine building block of significant interest in advanced organic synthesis. Its value lies in the versatile reactivity of the ethynyl group and the orthogonal protection of the amine, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of cyclobutane-containing drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Peptidomimetics & PROTACs: Serves as a versatile linker or component in the synthesis of peptide mimics and Proteolysis Targeting Chimeras (PROTACs) due to its rigid cyclobutane core and functional handles.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the cyclobutane ring can impart favorable biological activity and metabolic stability.
• Material Science Research: Employed as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with tailored properties.
• Chemical Biology Probes: Acts as a building block for creating molecular probes and tags used in bio-conjugation and target identification studies.
• Academic & Contract Research: A valuable reagent for methodology development and exploratory synthesis in academic laboratories and CROs (Contract Research Organizations).

Basic Information

Product Name	n-Boc-1-Ethynylcyclobutanamine
CAS No.	1268810-16-7
Molecular Formula	C11H17NO2
Molecular Weight	195.26 g/mol
Synonyms	1-Ethynylcyclobutanamine, N-Boc protected; tert-Butyl (1-ethynylcyclobutyl)carbamate; N-Boc-1-ethynylcyclobutan-1-amine; 1-[(tert-Butoxycarbonyl)amino]-1-ethynylcyclobutane; Boc-1-ethynylcyclobutanamine; (1-Ethynylcyclobutyl)carbamic acid tert-butyl ester; 1268810-16-7; N-Boc-1-Ethynylcyclobutylamine
EINECS	Contact for details

Quality Control

Our n-Boc-1-Ethynylcyclobutanamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications, and our quality commitment ensures reliable performance in your critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.