Description

(1S,3S)-3-Amino-N,n-Dimethylcyclobutane-1-Carboxamide CAS NO 1268521-02-3 is a high-purity, stereochemically defined cyclobutane derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold essential for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry, particularly in the development of novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in areas targeting central nervous system (CNS) disorders and metabolic diseases.
• Medicinal Chemistry Scaffold: Used to introduce the constrained cyclobutane ring and amide functionality into lead compounds to modulate potency, selectivity, and pharmacokinetic properties.
• Ligand and Probe Synthesis: Employed in the creation of chemical probes and high-affinity ligands for biological target validation and assay development.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to construct enantiomerically pure compounds.
• Peptidomimetics Development: Incorporated into peptide analogs to enhance metabolic stability and membrane permeability by replacing flexible peptide bonds.
• Agrochemical Research: Potential intermediate in the synthesis of novel, stereospecific agrochemicals and plant growth regulators.

Basic Information

Product Name	(1S,3S)-3-Amino-N,n-Dimethylcyclobutane-1-Carboxamide
CAS No.	1268521-02-3
Molecular Formula	C8H16N2O
Molecular Weight	156.23 g/mol
Synonyms	(1S,3S)-3-Amino-N,N-dimethylcyclobutane-1-carboxamide; (1S,3S)-3-Amino-N,N-dimethylcyclobutanecarboxamide; (1S,3S)-3-Amino-N,N-dimethyl-1-cyclobutanecarboxamide; rel-(1S,3S)-3-Amino-N,N-dimethylcyclobutane-1-carboxamide; (1S,3S)-Aminodimethylcyclobutanecarboxamide; cis-3-Amino-N,N-dimethylcyclobutane-1-carboxamide; Chiral Cyclobutane Carboxamide Derivative; Bicyclic Amine Carboxamide Intermediate
EINECS	Contact for details

Quality Control

Our (1S,3S)-3-Amino-N,n-Dimethylcyclobutane-1-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.