Description

(2R)-4-[(tert-Butyldiphenylsilyl)Oxy]-2-Fluorocyclohexan-1-One CAS NO 1268512-08-8 is a high-value, chiral fluorinated building block featuring a protected hydroxyl group. This compound is critical for the synthesis of complex molecules where stereochemical control and functional group manipulation are paramount. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for introducing fluorine atoms and protected alcohol functionalities into complex scaffolds.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the fluorinated cyclohexanone structure can enhance biological activity and metabolic stability.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in stereoselective chemical reactions, leveraging its defined (2R) configuration.
• Organofluorine Chemistry Research: A valuable compound for academic and industrial research focused on the synthesis and properties of fluorinated organic molecules.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke, high-value intermediates for client projects.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and advanced materials requiring specific fluorinated components.

Basic Information

Item	Details
Product Name	(2R)-4-[(tert-Butyldiphenylsilyl)Oxy]-2-Fluorocyclohexan-1-One
CAS No.	1268512-08-8
Molecular Formula	C22H27FO2Si
Molecular Weight	370.54 g/mol
Synonyms	(2R)-4-[(tert-Butyldiphenylsilyl)oxy]-2-fluorocyclohexanone; (R)-4-((tert-Butyldiphenylsilyl)oxy)-2-fluorocyclohexan-1-one; 4-[(1,1-Dimethylethyl)diphenylsilyl]oxy-2-fluorocyclohexanone, (2R)-; TBDPS-protected (R)-2-fluoro-4-hydroxycyclohexanone; 2-Fluoro-4-[(tert-butyldiphenylsilyl)oxy]cyclohexanone, (R)-; Fluorocyclohexanone TBDPS ether, (R)- isomer
EINECS	Contact for details

Quality Control

Our (2R)-4-[(tert-Butyldiphenylsilyl)Oxy]-2-Fluorocyclohexan-1-One is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding R&D and scale-up applications. All products undergo rigorous analytical testing, including chiral HPLC to confirm enantiomeric purity and NMR for structural verification. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.