Description

3-(2,5-Difluoro-Phenyl)-3-Oxo-Propionic Acid Methyl Ester is a high-purity fluorinated organic building block essential for advanced chemical synthesis. This compound serves as a critical intermediate in the development of complex molecules, particularly within the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for constructing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides that leverage its difluorophenyl moiety for enhanced biological activity.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals where fluorine incorporation modifies material properties.
• Chemical Development: Employed in process chemistry for scale-up and optimization of synthetic routes requiring this specific β-keto ester derivative.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including cross-coupling reactions and fluorination chemistry.

Basic Information

Product Name	3-(2,5-Difluoro-Phenyl)-3-Oxo-Propionic Acid Methyl Ester
CAS No.	1268103-31-6
Molecular Formula	C10H8F2O3
Molecular Weight	214.17 g/mol
Synonyms	Methyl 3-(2,5-difluorophenyl)-3-oxopropanoate; 3-Oxo-3-(2,5-difluorophenyl)propanoic acid methyl ester; Methyl 3-oxo-3-(2,5-difluorophenyl)propionate; 2,5-Difluoro-β-ketobutyric acid methyl ester; 3-(2,5-Difluorobenzoyl)propionic acid methyl ester; 1268103-31-6; Methyl 2,5-difluoro-β-ketobutyrate
EINECS	Contact for details

Quality Control

Our production of 3-(2,5-Difluoro-Phenyl)-3-Oxo-Propionic Acid Methyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.