Description

(3R)-Hydroxyquinidine-Vinyl-D3 is a high-purity, deuterated derivative of the cinchona alkaloid quinidine, specifically designed for advanced research and development applications. This compound is valued for its role as a chiral building block and a stable isotope-labeled internal standard in analytical chemistry. It is primarily utilized by researchers and process chemists in the pharmaceutical and fine chemical industries. The product is supplied with full analytical documentation to ensure traceability and support critical development work.

Application

• Pharmaceutical Research: Serves as a key chiral intermediate or precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for cardiovascular and anti-malarial drug candidates.
• Analytical Chemistry: Used as a stable isotope-labeled internal standard (D3-labeled) for the precise quantification of quinidine and related metabolites in complex biological matrices via LC-MS/MS.
• Asymmetric Catalysis: Employed as a chiral ligand or catalyst modifier in stereoselective synthesis, leveraging the quinidine scaffold's ability to induce enantioselectivity.
• Metabolic Studies: Facilitates drug metabolism and pharmacokinetics (DMPK) research by tracking the fate of the quinidine moiety in in vitro and in vivo studies.
• Reference Standard: Provides a certified reference material for method development, validation, and quality control in analytical laboratories.
• Chemical Biology: Acts as a molecular probe to study ion channel interactions or other biological targets associated with the quinidine pharmacophore.

Basic Information

Product Name	(3R)-Hydroxyquinidine-Vinyl-D3
CAS No.	1267650-60-1
Molecular Formula	C20H23D3N2O2
Molecular Weight	329.46 g/mol (approx.)
Synonyms	(3R)-Hydroxyquinidine-vinyl-d3; (8α,9R)-6'-Methoxycinchonan-9-ol, 10,11-didehydro-, 3-ethenyl-d3; Quinidine, 3-hydroxy-, 3-vinyl-d3; Deuterated (3R)-Hydroxyquinidine Vinyl; 3-Vinyl-d3-(3R)-hydroxyquinidine; (3R)-10,11-Didehydro-6'-methoxycinchonan-9-ol, 3-ethenyl-d3
EINECS	Contact for details

Quality Control

Our (3R)-Hydroxyquinidine-Vinyl-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, NMR and MS for structural confirmation and isotopic enrichment, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.