Description

7'-Fluoro-2',3'-Dihydro-1'H-Spiro[Cyclohexane-1,4'-Isoquinoline] is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and fluorinated isoquinoline structure. This compound is of significant value in modern medicinal chemistry for its role as a key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug molecules, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorinated Compound Synthesis: Serves as a specialized fluorinated building block to introduce metabolic stability and modulate bioavailability in lead compounds.
• Spirocyclic Compound Development: Provides the core spiro[cyclohexane-isoquinoline] structure for exploring novel three-dimensional chemical space in drug design.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for studying fluorination effects and spirocyclic chemistry.

Basic Information

Product Name	7'-Fluoro-2',3'-Dihydro-1'H-Spiro[Cyclohexane-1,4'-Isoquinoline]
CAS No.	1266894-81-8
Molecular Formula	C14H16FN
Molecular Weight	217.28 g/mol
Synonyms	7'-Fluoro-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-isoquinoline]; 1'H-Spiro[cyclohexane-1,4'-isoquinoline], 7'-fluoro-2',3'-dihydro-; Spiro[cyclohexane-1,4'-isoquinoline], 7'-fluoro-2',3'-dihydro-1'H-; 7-Fluoro-1,2,3,4-tetrahydrospiro[isoquinoline-4,1'-cyclohexane]; 7-Fluoro-2,3-dihydro-1H-spiro[isoquinoline-4,1'-cyclohexane]; 7-Fluoro-1,2,3,4-tetrahydrospiro[cyclohexane-1,4'-isoquinoline]; 1266894-81-8
EINECS	Contact for details

Quality Control

Our 7'-Fluoro-2',3'-Dihydro-1'H-Spiro[Cyclohexane-1,4'-Isoquinoline] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment. We adhere to cGMP guidelines for the production of pharmaceutical intermediates to ensure reliable and consistent quality for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.