Description

1-Bromo-2-Ethoxy-4,5-Difluorobenzene is a high-purity halogenated aromatic ether building block of significant interest in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides a versatile and reactive scaffold for constructing complex molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications such as drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing difluorobenzene and aryl ether motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the bromine and fluorine atoms offer sites for further functionalization.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig couplings to form new carbon-carbon and carbon-heteroatom bonds.
• Ligand and Catalyst Development: Utilized as a precursor for synthesizing complex chelating ligands used in homogeneous catalysis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological systems and target identification.

Basic Information

Product Name	1-Bromo-2-Ethoxy-4,5-Difluorobenzene
CAS No.	1266253-71-7
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	2-Bromo-1-ethoxy-4,5-difluorobenzene; 4,5-Difluoro-2-bromo-1-ethoxybenzene; Benzene, 1-bromo-2-ethoxy-4,5-difluoro-; 1-Ethoxy-2-bromo-4,5-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Ethoxy-4,5-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.