Description

Ticagrelor-D7 CAS NO 1265911-55-4 is a deuterated analog of the antiplatelet drug Ticagrelor, specifically labeled with seven deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for quantitative bioanalytical methods, ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities involved in drug development and regulatory compliance.

Application

• Primary use as an Internal Standard (IS) in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of Ticagrelor and its metabolites in biological matrices.
• Critical component in Pharmacokinetic (PK) and Bioequivalence (BE) studies to ensure precise and accurate measurement of drug concentration over time.
• Utilized in Drug Metabolism and Pharmacokinetics (DMPK) research to investigate the metabolic pathways and stability of Ticagrelor.
• Essential for Regulatory Submissions to agencies like the FDA and EMA, providing validated data for new drug applications (NDAs).
• Used in the development and validation of High-Performance Liquid Chromatography (HPLC) and Ultra-Performance Liquid Chromatography (UPLC) analytical methods.
• Applied in Clinical Research to monitor patient drug levels and study drug-drug interactions involving Ticagrelor.
• Serves as a certified reference material (CRM) for Quality Control (QC) in the manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Ticagrelor-D7
CAS No.	1265911-55-4
Molecular Formula	C23H21D7F2N6O4S
Molecular Weight	~ 534.6 g/mol
Synonyms	(1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol-d7; AZD6140-d7; AR-C126532XX-d7; Brilinta-d7; Brillinta-d7; Ticagrelor (heptadeuterated); Ticagrelor-d7 Internal Standard
EINECS	Contact for details

Quality Control

Our Ticagrelor-D7 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment, suitable for sensitive analytical applications. Each batch undergoes comprehensive testing, including HPLC for chemical purity, NMR and MS for structural confirmation, and isotopic purity analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.