Description

3-Fluoro-5-(1-Pyrrolidinylcarbonyl)Benzeneboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a pyrrolidine amide moiety that can influence solubility and binding properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly for creating complex biaryl and heterobiaryl structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for drug discovery programs, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to construct novel herbicide and fungicide candidates through palladium-catalyzed cross-coupling reactions.
• Material Science: Employed in the development of organic electronic materials, such as polymers for OLEDs, where the boronic acid group enables precise molecular assembly.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors targeting enzymes like proteases.
• Ligand Synthesis: Serves as a starting material for creating novel bidentate or tridentate ligands used in catalysis.
• Library Synthesis for High-Throughput Screening: A valuable building block for generating diverse compound libraries in medicinal chemistry to explore new chemical space.

Basic Information

Product Name	3-Fluoro-5-(1-Pyrrolidinylcarbonyl)Benzeneboronic Acid
CAS No.	1264616-18-3
Molecular Formula	C11H13BFNO3
Molecular Weight	237.04 g/mol
Synonyms	(3-Fluoro-5-(pyrrolidine-1-carbonyl)phenyl)boronic acid; 3-Fluoro-5-(pyrrolidine-1-carbonyl)benzeneboronic acid; 5-Borono-3-fluoro-N-pyrrolidinylbenzamide; 3-Fluoro-5-(N-pyrrolidinylcarbonyl)phenylboronic acid; B-[3-Fluoro-5-(1-pyrrolidinylcarbonyl)phenyl]boronic acid; 1264616-18-3; AKOS026710915
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(1-Pyrrolidinylcarbonyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and consistency for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.