Description

o-Tbdps-D-Thr-n-Boc-L-tert-Leu-Diphenylphosphine CAS NO 1264520-63-9 is a sophisticated, multi-functional protected amino acid derivative and phosphine reagent designed for advanced synthetic chemistry. This compound is critically important for its dual role in facilitating complex peptide coupling reactions and serving as a chiral ligand or auxiliary in asymmetric synthesis. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing novel therapeutic peptides and complex organic molecules.

Application

• Peptide Synthesis: As a key building block for the solid-phase or solution-phase synthesis of complex peptides containing threonine and tert-leucine residues, offering orthogonal protection with TBDPS and Boc groups.
• Asymmetric Catalysis: Utilized as a chiral phosphine ligand in transition-metal catalyzed reactions, such as asymmetric hydrogenations or cross-couplings, to induce high enantioselectivity.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for metabolic diseases and oncology targets.
• Protecting Group Strategy: Enables complex multi-step synthetic sequences where selective deprotection of the acid-labile Boc group or fluoride-labile TBDPS group is required.
• Ligand Synthesis: Acts as a precursor for the development of novel bidentate or monodentate phosphine ligands used in homogeneous catalysis.
• Academic & Process Chemistry: Employed in research institutions and process development labs for method development and scaling up novel synthetic routes.

Basic Information

Product Name	o-Tbdps-D-Thr-n-Boc-L-tert-Leu-Diphenylphosphine
CAS No.	1264520-63-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(2S)-2-[(2R)-3-[[tert-Butyl(diphenyl)silyl]oxy]-2-[(tert-butoxycarbonyl)amino]butanoyl]amino]-3,3-dimethyl-N-(diphenylphosphanyl)butanamide; N-[(Diphenylphosphino)]-O-(tert-butyldiphenylsilyl)-N-Boc-D-threonyl-L-tert-leucinamide; D-Thr(TBDPS)-N-Boc-L-tert-Leu-PPh2; TBDPS-D-Thr(Boc)-L-t-Leu-Diphenylphosphine; Boc-D-Thr(TBDPS)-L-tert-Leu-PPh2; Protected D-Threonine-L-tert-Leucine Phosphine Derivative; Amino Acid-Derived Chiral Phosphine
EINECS	Contact for details

Quality Control

Our o-Tbdps-D-Thr-n-Boc-L-tert-Leu-Diphenylphosphine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical R&D and scale-up applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its sensitivity to oxidation and moisture. Allow the sealed container to reach room temperature before opening to prevent condensation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.