Description

Triamcinolone-13C3 Acetonide is a stable isotope-labeled analog of the potent synthetic glucocorticoid, triamcinolone acetonide, where three carbon atoms are replaced with the carbon-13 isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry-based bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance testing for corticosteroid therapies.

Application

• Primary use as an Internal Standard (IS) in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantitative analysis of triamcinolone acetonide.
• Enabling precise bioavailability and bioequivalence studies for generic and novel drug formulations containing triamcinolone acetonide.
• Facilitating metabolite identification and profiling in in vitro and in vivo metabolism studies.
• Supporting clinical trial analysis by providing a stable reference for accurate measurement of drug concentrations in biological matrices (plasma, serum, urine, tissue).
• Use in doping control analysis in sports to detect and confirm the presence of synthetic corticosteroids.
• Application in veterinary pharmaceutical analysis for corticosteroid-containing treatments.
• Critical component in regulated laboratory environments following Good Laboratory Practice (GLP) and FDA/EMA guidelines.

Basic Information

Product Name	Triamcinolone-13C3 Acetonide
CAS No.	1264131-86-3
Molecular Formula	C24H31FO6 (with three 13C atoms)
Molecular Weight	~ 441.5 g/mol (13C-adjusted)
Synonyms	9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone-13C3; 9α-Fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene-13C3)bis(oxy)]pregna-1,4-diene-3,20-dione; Triamcinolone Acetonide-13C3; [13C3]-Triamcinolone Acetonide; Triamcinolone-13C3 16,17-Acetonide; Isotopically Labeled Triamcinolone Acetonide; 13C3-Triamcinolone Acetonide
EINECS	Contact for details

Quality Control

Every batch of Triamcinolone-13C3 Acetonide is manufactured and analyzed under strict quality systems to ensure it meets the exacting standards required for analytical internal standards. Our products undergo rigorous quality testing, including isotopic purity and chemical purity assessments, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as isotopic enrichment, chemical purity (by HPLC), and identity confirmation (by NMR and MS).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C3)	≥ 99 atom % 13C
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.