Description

(3R,7Ar)-3-(Trichloromethyl)Tetrahydro-1H-Pyrrolo[1,2-C][1,3]Oxaz Ol-1-One CAS NO 1263774-42-0 is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused oxazolidinone-pyrrolidine structure. This compound is a critical chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs), offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting the central nervous system or infectious diseases.
• Asymmetric Synthesis: Used as a precursor or reagent in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Process Chemistry Development: Integral to scaling up synthetic routes from laboratory to pilot plant and commercial production for new APIs.
• Agrochemical Intermediate: Potential application in the synthesis of advanced, chiral agrochemicals requiring specific biological activity.

Basic Information

Product Name	(3R,7Ar)-3-(Trichloromethyl)Tetrahydro-1H-Pyrrolo[1,2-C][1,3]Oxaz Ol-1-One
CAS No.	1263774-42-0
Molecular Formula	C8H8Cl3NO2
Molecular Weight	256.51 g/mol
Synonyms	(3R,7aR)-3-(Trichloromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-1-one; (3R,7aR)-3-(Trichloromethyl)hexahydropyrrolo[1,2-c]oxazol-1-one; 3-(Trichloromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-1-one (enantiomer); 1263774-42-0; Pyrrolooxazolidinone derivative; Trichloromethyl pyrrolooxazolidinone; Chiral oxazolidinone intermediate
EINECS	Contact for details

Quality Control

Every batch of our (3R,7Ar)-3-(Trichloromethyl)Tetrahydro-1H-Pyrrolo[1,2-C][1,3]Oxaz Ol-1-One is manufactured and tested under strict quality management systems. We ensure compliance with ICH Q7 guidelines for pharmaceutical intermediates. Comprehensive analytical testing, including chiral purity verification, is performed. A detailed Certificate of Analysis (COA) confirming identity, purity, and enantiomeric excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.