Description

n-Boc-n-Deshydroxyethyl Dasatinib-D8 is a deuterated, Boc-protected derivative of the tyrosine kinase inhibitor Dasatinib. This compound is a critical stable isotope-labeled intermediate used in the synthesis of isotopically labeled drug substances for pharmaceutical research and development. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic laboratories engaged in advanced drug metabolism, pharmacokinetic (DMPK) studies, and the development of bioanalytical methods.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, high-purity internal standard for the quantitative bioanalysis of Dasatinib and its metabolites in biological matrices.
• Metabolite Identification & Tracing: Used in drug metabolism studies (ADME) to trace and identify metabolites due to its deuterium labeling, providing clear mass spectrometric differentiation.
• Synthetic Intermediate: Acts as a key building block in the custom synthesis of deuterated Dasatinib analogs for specialized research applications.
• Pharmacokinetic (PK) Research: Essential for conducting precise and reliable pharmacokinetic studies to understand the absorption, distribution, metabolism, and excretion of Dasatinib.
• Reference Standard Development: Used in the preparation and qualification of certified reference standards for regulatory submissions.

Basic Information

Product Name	n-Boc-n-Deshydroxyethyl Dasatinib-D8
CAS No.	1263379-04-9
Molecular Formula	C26H26D8ClN7O3S
Molecular Weight	552.12 g/mol (for deuterated form)
Synonyms	tert-Butyl (2S)-4-[(2-chloro-6-methyl-5-pyrimidinyl)amino]-2-[[4-[(2,4-dichlorophenyl)methyl]-1-piperazinyl](methyl-d2)]-2-hydroxy-4-oxobutyl(methyl-d3)carbamate; Dasatinib-d8 N-Boc N-Deshydroxyethyl Intermediate; BMS-354825-d8 Derivative; Deuterated Dasatinib Boc-Protected Intermediate; N-[(1,1-Dimethylethoxy)carbonyl]-N-des(2-hydroxyethyl)-Dasatinib-d8
EINECS	Contact for details

Quality Control

Our n-Boc-n-Deshydroxyethyl Dasatinib-D8 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and impurity profile. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates, ensuring traceability and consistency for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.