Description

5-Acetyl-2-Bromo-Benzonitrile is a versatile and high-value brominated aromatic nitrile building block. This compound matters for its unique molecular architecture, combining an acetyl ketone, a bromine substituent, and a nitrile group, which enables diverse chemical transformations in advanced synthesis. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the bromine atom serves as a handle for further functionalization.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its rigid aromatic core and reactive sites.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitutions due to the reactive bromine atom.
• Chemical Reference Standard: Used in analytical laboratories for method development and quality control of related substances.

Basic Information

Product Name	5-Acetyl-2-Bromo-Benzonitrile
CAS No.	1263285-73-9
Molecular Formula	C9H6BrNO
Molecular Weight	224.05 g/mol
Synonyms	2-Bromo-5-acetylbenzonitrile; 1-(3-Bromo-4-cyanophenyl)ethan-1-one; 3'-Bromo-4'-cyanoacetophenone; 5-Acetyl-2-bromobenzonitrile; 2-Bromo-5-cyanobenzophenone (common misnomer); 5-Acetyl-2-bromophenyl cyanide
EINECS	Contact for details

Quality Control

Our 5-Acetyl-2-Bromo-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.