Description

Ethyl 4-Fluorobenzo[B]Thiophene-2-Carboxylate is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce the benzo[b]thiophene scaffold with specific fluorination patterns.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the fluorobenzo[b]thiophene moiety can enhance biological activity and environmental stability.
• Material Science: Acts as a building block for organic electronic materials, such as organic semiconductors and light-emitting diodes (OLEDs), due to its conjugated system.
• Chemical Biology Probes: Employed in the design and synthesis of fluorescent tags and molecular probes for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Ethyl 4-Fluorobenzo[B]Thiophene-2-Carboxylate
CAS No.	1263280-02-9
Molecular Formula	C11H9FO2S
Molecular Weight	224.25 g/mol
Synonyms	Ethyl 4-Fluorobenzo[b]thiophene-2-carboxylate; 4-Fluorobenzo[b]thiophene-2-carboxylic Acid Ethyl Ester; 2-Carbethoxy-4-fluorobenzo[b]thiophene; Ethyl 4-Fluoro-1-benzothiophene-2-carboxylate; Benzo[b]thiophene-2-carboxylic acid, 4-fluoro-, ethyl ester; 1263280-02-9; 4-Fluoro-benzo[b]thiophene-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Fluorobenzo[B]Thiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.