Description

Norgestimate-D6 (Major) is a high-purity, deuterium-labeled internal standard of the synthetic progestin norgestimate, essential for precise quantitative analysis. This compound is critical for ensuring accuracy and reliability in sensitive analytical methods, particularly in pharmaceutical research and development. It is primarily used by analytical laboratories and pharmaceutical companies engaged in method development, pharmacokinetic studies, and quality control testing of hormonal products.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of norgestimate and its metabolites in complex biological matrices like plasma and urine.
• Pharmaceutical R&D: Supports method development and validation for bioanalytical studies, pharmacokinetics, and drug metabolism research.
• Quality Control & Assurance: Enables precise assay and impurity profiling of norgestimate in active pharmaceutical ingredients (APIs) and finished drug products.
• Clinical Research: Facilitates reliable measurement of drug levels in clinical trial samples for hormonal contraceptives and hormone replacement therapies.
• Forensic & Doping Analysis: Applied in specialized testing laboratories for the detection and confirmation of progestin compounds.
• Environmental Monitoring: Potential use as a reference standard in trace analysis of pharmaceutical residues in environmental samples.

Basic Information

Item	Details
Product Name	Norgestimate-D6 (Major)
CAS No.	1263194-12-2
Molecular Formula	C₂₃H₂₅D₆NO₅
Molecular Weight	407.55 g/mol (approx.)
Synonyms	17α-Ethynyl-17β-acetoxy-13-ethyl-18,19-dinor-4,15-pregnadien-20-yn-3-one 3-oxime-D6; (17α)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregna-4,15-dien-20-yn-3-one 3-oxime-D6; 13-Ethyl-17α-ethynyl-17β-hydroxy-18,19-dinor-4,15-pregnadien-20-yn-3-one oxime acetate-D6; Deuterated Norgestimate; Norgestimate D6; Norgestimate-d6; Norgestimate Internal Standard
EINECS	Contact for details

Quality Control

Our Norgestimate-D6 (Major) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity and NMR/MS for structural confirmation and isotopic enrichment verification. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing batch-specific results for identity, purity (assay), and chemical properties. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.