Description

Limaprost-D3 is a high-purity, deuterated analog of Limaprost, a synthetic prostaglandin E1 derivative. This compound is specifically designed for use as a critical internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D and clinical laboratories focused on developing and monitoring prostaglandin-based therapies, particularly for circulatory disorders.

Application

• Bioanalytical Reference Standard: Serves as a stable isotope-labeled internal standard (SIL-IS) for the precise quantification of Limaprost in biological matrices (plasma, serum, tissue) via LC-MS/MS.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Critical for developing robust, sensitive, and selective analytical methods in compliance with GLP and ICH guidelines.
• Drug Impurity Profiling: Used in stability studies and impurity characterization to understand degradation pathways.
• Pharmaceutical Quality Control: Supports assay and content uniformity testing for drug product manufacturing under GMP.

Basic Information

Product Name	Limaprost-D3
CAS No.	1263190-37-9
Molecular Formula	C₂₃H₃₅D₃O₆
Molecular Weight	~413.6 g/mol
Synonyms	Limaprost-d3; Deuterated Limaprost; (5Z,13E)-(9S,11R,15S)-9,11,15-Trihydroxy-17,18,18-trideuterioprosta-5,13-dien-1-oic acid; OP-1206-d3; Prostaglandin E1 derivative-d3; α-Cyclodextrin clathrate-d3 (if applicable); 17,18,18-trideuterio-Limaprost
EINECS	Contact for details

Quality Control

Every batch of Limaprost-D3 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles, ensuring compliance with the rigorous standards required for analytical reference materials. Our quality commitment supports your adherence to GMP, GLP, and ICH Q2(R1) guidelines for method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.