Description

Endo-Bcn-Peg3-Biotin is a high-purity, bifunctional chemical linker designed for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and manufacturers requiring precise, stable, and efficient coupling of biomolecules, such as antibodies or peptides, to various surfaces, probes, or drug delivery systems. It is primarily utilized in the pharmaceutical, diagnostic, and life science research sectors for developing targeted therapeutics, advanced imaging agents, and sophisticated assay platforms.

Application

• ADC (Antibody-Drug Conjugate) Development: Serves as a cleavable linker for attaching cytotoxic payloads to monoclonal antibodies.
• Proteomics and Biomarker Discovery: Used for labeling and enriching proteins or peptides for mass spectrometry analysis.
• Diagnostic Assay Fabrication: Enables the stable immobilization of capture antibodies or antigens on biosensor surfaces and microplates.
• Drug Delivery System Engineering: Facilitates the functionalization of nanoparticles, liposomes, and polymers for targeted delivery.
• Bioorthogonal Labeling: Utilized in live-cell imaging and tracking studies via strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry with its BCN group.
• Avidin/Biotin Technology: The biotin moiety allows for strong, specific capture or detection using streptavidin-coated beads, columns, or surfaces.

Basic Information

Product Name	Endo-Bcn-Peg3-Biotin
CAS No.	1263166-92-2
Molecular Formula	C₃₃H₅₆N₄O₈S
Molecular Weight	668.89 g/mol
Synonyms	Biotin-PEG3-BCN; BCN-PEG3-Biotin; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-((2-(2-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)ethoxy)ethyl)carbamate; BCN-PEG₃-Biotin; Endo-BCN-PEG₃-Biotin; Biotin-PEG₃-endo-BCN; Biotin-PEG3-azadibenzocyclooctyne
EINECS	Contact for details

Quality Control

Our Endo-Bcn-Peg3-Biotin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.