Description

Endo Bcn-o-Pnb CAS NO 1263166-91-1 is a specialized bifunctional linker compound featuring both bicyclo[6.1.0]nonyne (BCN) and para-nitrobenzyl (PNB) protecting groups. This chemical is engineered for advanced bioconjugation and click chemistry applications, enabling precise and efficient modification of biomolecules under mild conditions. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require high-purity, reliable building blocks for complex synthesis.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Synthesis: Serves as a key linker for attaching cytotoxic payloads to monoclonal antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry.
• Proteomics and Biomolecule Labeling: Used for site-specific labeling of proteins, peptides, and oligonucleotides for imaging, tracking, and functional studies.
• Polymer and Materials Science: Acts as a functional monomer or cross-linker for creating smart hydrogels, surface coatings, and functionalized nanomaterials with responsive properties.
• Chemical Biology Tool Development: Enables the construction of activity-based probes and diagnostic agents for target identification and validation in drug discovery.
• Prodrug Design: Utilized in the development of prodrugs where the PNB group provides a cleavable linker for controlled drug release triggered by specific enzymes or light.

Basic Information

Product Name	Endo Bcn-o-Pnb
CAS No.	1263166-91-1
Molecular Formula	C₂₂H₂₈N₂O₄
Molecular Weight	384.47 g/mol
Synonyms	(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (4-nitrophenyl) carbonate; endo-BCN-O-PNB; BCN-O-PNB Ester; BCN-PNB Carbonate; BCN-(4-Nitrophenyl) Carbonate; BCN-PNB Linker; BCN Active Ester; BCN-PNB Carbonate Reagent
EINECS	Contact for details

Quality Control

Our Endo Bcn-o-Pnb is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. The compound is light-sensitive and should be handled under inert atmosphere when appropriate to maximize shelf life.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.