Description

Beclomethasone-D5 is a deuterated analog of the potent glucocorticoid steroid beclomethasone, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D and quality control laboratories requiring precise measurement of beclomethasone levels in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering internal standard for the accurate quantification of beclomethasone in bioanalytical assays.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of beclomethasone.
• Clinical Trial Analysis: Enables precise measurement of drug concentrations in patient plasma, serum, or urine samples during clinical trials for asthma and COPD treatments.
• Forensic and Doping Control: Supports the detection and confirmation of beclomethasone misuse in sports or forensic toxicology investigations.
• Method Development and Validation: Serves as a key component in developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Manufacturing: Used in in-process testing and final product release assays to ensure the consistency and potency of beclomethasone-containing pharmaceutical formulations.

Basic Information

Product Name	Beclomethasone-D5
CAS No.	1263143-48-1
Molecular Formula	C28H32D5ClO7
Molecular Weight	~ 525.5 g/mol
Synonyms	9,21-Dichloro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione-17,21-dipropionate-d5; Beclometasone-D5; Beclomethasone Dipropionate-d5; 9α-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate-d5; Beclomethasone-17,21-Dipropionate-d5; Deuterated Beclomethasone Dipropionate; Beclomethasone-d5 Internal Standard
EINECS	Contact for details

Quality Control

Our Beclomethasone-D5 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (by MS), and residual solvents. We support compliance with cGMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.