Description

Fmoc-Dab(Dnp)-Oh CAS NO 1263047-22-8 is a protected amino acid derivative, specifically featuring Fmoc (9-fluorenylmethoxycarbonyl) and Dnp (2,4-dinitrophenyl) protecting groups on the side chain of 2,4-diaminobutyric acid (Dab). This compound is a critical building block in the solid-phase peptide synthesis (SPPS) of complex peptides, enabling the orthogonal protection and selective deprotection of side-chain functionalities. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled assembly of peptides containing 2,4-diaminobutyric acid residues.
• Pharmaceutical Research & Development: Used in the synthesis of novel peptide-based drug candidates, including antimicrobial peptides and hormone analogs.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-protein conjugates for diagnostic and imaging applications.
• Chemical Biology Studies: Employed to incorporate modified Dab residues into peptides to study protein-protein interactions and enzyme mechanisms.
• Custom Peptide Service Providers: A vital raw material for CROs and CDMOs offering bespoke peptide synthesis services to academic and industrial clients.

Basic Information

Product Name	Fmoc-Dab(Dnp)-Oh
CAS No.	1263047-22-8
Molecular Formula	C26H24N4O8
Molecular Weight	520.49 g/mol
Synonyms	Fmoc-Dab(Dnp)-OH; Fmoc-L-Dab(Dnp)-OH; Nα-Fmoc-Nγ-Dnp-L-2,4-diaminobutyric acid; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-[(2,4-dinitrophenyl)amino]butanoic acid; Fmoc-Dab(Dnp)-OH CAS 1263047-22-8; Fmoc-L-2,4-diaminobutyric acid(Dnp)-OH; Nα-Fmoc-Nγ-(2,4-dinitrophenyl)-L-2,4-diaminobutyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-Dab(Dnp)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistency and compliance with research and cGMP-grade requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.