Description

(2R)-3-(1,3-Benzothiazol-2-Yl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid is a sophisticated, non-natural amino acid derivative featuring both Fmoc (9-fluorenylmethoxycarbonyl) and benzothiazole protecting/functional groups. This compound is of significant value in advanced organic synthesis and peptide research, where it serves as a critical building block for introducing specific structural motifs and fluorescence properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostic probes, and materials science applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a key intermediate for the automated synthesis of custom peptides containing the benzothiazole moiety.
• Fluorescent Probe Development: The benzothiazole group can impart fluorescent characteristics, making it valuable for creating labeled peptides for bioimaging and diagnostic assays.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new drug candidates, particularly for targets where the benzothiazole scaffold is pharmacologically relevant.
• Chemical Biology Tools: Incorporation into peptides to study protein-protein interactions, enzyme activity, or cellular uptake mechanisms.
• Material Science: Potential use in the synthesis of functionalized polymers or supramolecular assemblies where specific optical or binding properties are desired.

Basic Information

Product Name	(2R)-3-(1,3-Benzothiazol-2-Yl)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid
CAS No.	1263047-16-0
Molecular Formula	C25H20N2O4S
Molecular Weight	444.50 g/mol
Synonyms	Fmoc-3-(2-benzothiazolyl)-D-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(1,3-benzothiazol-2-yl)-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(benzo[d]thiazol-2-yl)propanoic acid; Fmoc-D-Bta-OH; Fmoc-3-(2-benzothiazolyl)-D-Ala-OH; Nα-Fmoc-3-(2-benzothiazolyl)-D-alanine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.