Description

Dde-D-Dab(Fmoc)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling complex, multi-step peptide assembly by providing selective deprotection strategies, thereby increasing synthetic efficiency and yield. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on creating novel peptide-based therapeutics and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of complex peptides, particularly those requiring orthogonal protection schemes.
• Pharmaceutical R&D: Used in the research and development of novel peptide drugs, hormones, and diagnostic agents where precise sequence control is paramount.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening against biological targets.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.
• Chemical Biology Studies: Utilized to incorporate specific, protected amino acids into peptides for studying protein-protein interactions and enzyme mechanisms.
• Custom Peptide Service Providers: A critical raw material for CROs and CDMOs offering bespoke peptide synthesis services to the biotech and pharmaceutical industries.

Basic Information

Product Name	Dde-D-Dab(Fmoc)-Oh
CAS No.	1263046-84-9
Molecular Formula	C30H35N3O7
Molecular Weight	549.62 g/mol
Synonyms	Fmoc-D-Dab(Dde)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-[(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino]butanoic acid; Nα-Fmoc-Nγ-Dde-D-2,4-diaminobutyric acid; D-Dab(Dde)-Fmoc; Fmoc-D-Dab(Dde)-OH CAS 1263046-84-9; Nγ-(1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl)-Nα-Fmoc-D-2,4-diaminobutyric acid
EINECS	Contact for details

Quality Control

Our Dde-D-Dab(Fmoc)-Oh is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.