Description

Dde-D-Dab(Alloc)-Oh is a specialized, orthogonally protected dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling complex, multi-step synthetic strategies, particularly in the production of challenging peptide sequences. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of peptide chains, especially those requiring selective deprotection strategies.
• Orthogonal Protection Schemes: Utilized in Fmoc/t-Bu and Boc/Bzl synthesis strategies where the Dde (1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl) and Alloc (Allyloxycarbonyl) protecting groups allow for selective deprotection in the presence of other standard protecting groups.
• Synthesis of Complex Peptides: Essential for constructing peptides containing the uncommon amino acid 2,4-diaminobutyric acid (Dab), which is found in various natural products and bioactive compounds.
• Pharmaceutical Research: Serves as a building block in the research and development of peptide-based drugs, including antimicrobial peptides (AMPs) and hormone analogs.
• Bioconjugation and Labeling: The orthogonal protecting groups facilitate site-specific modification and labeling of peptides for diagnostic or targeting applications.
• Chemical Biology Tool Development: Used to create probes and inhibitors for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	Dde-D-Dab(Alloc)-Oh
CAS No.	1263046-79-2
Molecular Formula	C₂₀H₃₁N₃O₇
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-D-Dab(Alloc)-OH; Nα-Fmoc-Nγ-Alloc-D-2,4-diaminobutyric acid; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-[(prop-2-en-1-yloxy)carbonylamino]butanoic acid; D-2,4-Diaminobutyric acid, Nα-Fmoc-Nγ-Alloc-; Alloc-D-Dab(Fmoc)-OH; D-Dab(Alloc, Fmoc)-OH; Nγ-Alloc-Nα-Fmoc-D-diaminobutyric acid
EINECS	Contact for details

Quality Control

Our Dde-D-Dab(Alloc)-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.