Description

Dde-L-Dab(Fmoc)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for enabling complex peptide assembly by providing selective deprotection strategies, thereby facilitating the synthesis of challenging sequences and modified peptides. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and the production of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, allowing for the controlled incorporation of diaminobutyric acid (Dab).
• Orthogonal Protection Schemes: The Dde (1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl) protecting group on the side-chain amine can be selectively removed under mild conditions (e.g., hydrazine) while the Fmoc group on the α-amine remains intact.
• Synthesis of Modified and Labeled Peptides: Enables the site-specific introduction of functional groups, fluorescent tags, or other moieties onto the Dab side chain after selective Dde deprotection.
• Pharmaceutical R&D: Used in the research and development of novel peptide drugs, including antimicrobial peptides (AMPs) and hormone analogs.
• Combinatorial Chemistry: A valuable reagent for generating diverse peptide libraries for drug discovery and screening purposes.
• Bioconjugation: Serves as a precursor for creating peptide conjugates with proteins, polymers, or surfaces for diagnostic and material science applications.

Basic Information

Product Name	Dde-L-Dab(Fmoc)-Oh
CAS No.	1263045-85-7
Molecular Formula	C28H31N3O6
Molecular Weight	505.56 g/mol
Synonyms	Fmoc-Dab(Dde)-OH; Nα-Fmoc-Nγ-Dde-L-2,4-diaminobutyric acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)amino)butanoic acid; Fmoc-L-Dab(Dde)-OH; Nα-Fmoc-Nγ-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)-L-2,4-diaminobutyric acid; Fmoc-Dab(Dde)-OH (Dde side chain protection); L-Dab(Fmoc,Dde)-OH
EINECS	Contact for details

Quality Control

Our Dde-L-Dab(Fmoc)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistency and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.