Description

Rifaximin-D6 CAS NO 1262992-43-7 is a deuterium-labeled isotopologue of the broad-spectrum antibiotic rifaximin, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is critical for ensuring the accuracy and reliability of mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS/MS) analyses. It is an essential tool for pharmaceutical research and development, clinical laboratories, and regulatory agencies involved in pharmacokinetic studies, bioequivalence testing, and quality control of rifaximin-based formulations.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a stable, non-interfering internal standard for the precise quantification of rifaximin in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing robust, sensitive, and reproducible analytical methods compliant with FDA, EMA, and ICH guidelines.
• Drug Metabolism Research: Used in metabolite identification and profiling studies due to its distinct mass shift from the non-deuterated compound.
• Quality Control in Pharmaceutical Manufacturing: Supports assay and impurity profiling of rifaximin active pharmaceutical ingredient (API) and finished drug products.
• Forensic and Anti-Doping Analysis: Provides a reliable reference for detecting and quantifying rifaximin in specialized testing scenarios.

Basic Information

Product Name	Rifaximin-D6
CAS No.	1262992-43-7
Molecular Formula	C43H45D6N3O11
Molecular Weight	792.90 g/mol
Synonyms	Rifaximin (hexadeuterated); Rifaximin-d6; 4-Deoxy-4'-methylpyrido[1',2'-1,2]imidazo[5,4-c]rifamycin SV-d6; (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,6,21,23,25-Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione-d6; L-105-d6; Normix-d6; Xifaxan-d6; Rifamycin L-105-d6
EINECS	Contact for details

Quality Control

Every batch of Rifaximin-D6 is manufactured and analyzed under strict quality systems to ensure the highest standards of isotopic purity and chemical identity required for analytical reference standards. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed batch-specific data, including isotopic enrichment, chemical purity, and results from all specification tests.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. The product is light-sensitive and should be stored away from light. Keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Orange-red to brownish-red powder
Identification (HPLC-MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.