Description

(R)-n-Fmoc-2-(7'-Octeny)Glycine is a high-purity, non-natural amino acid derivative featuring a unique olefinic side chain. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, enabling the introduction of structural diversity and specific functional handles. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, medicinal chemistry, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid for the controlled incorporation of the (R)-2-(7'-octenyl)glycine residue into peptide chains.
• Medicinal Chemistry & Drug Discovery: A key intermediate for constructing peptide-based libraries to screen for new bioactive compounds and optimize lead molecules.
• Peptidomimetic Design: Used to create modified peptides with enhanced stability, bioavailability, or receptor binding affinity by introducing hydrophobic, aliphatic side chains.
• Chemical Biology Probes: The terminal alkene group serves as a versatile handle for further functionalization via click chemistry (e.g., thiol-ene, hydroamination) to attach labels, tags, or other biomolecules.
• GPCR Ligand Development: Particularly relevant for synthesizing analogs of peptide hormones and neurotransmitters where side chain modification is crucial for activity.

Basic Information

Product Name	(R)-n-Fmoc-2-(7'-Octeny)Glycine
CAS No.	1262886-63-4
Molecular Formula	C26H31NO4
Molecular Weight	421.53 g/mol
Synonyms	Fmoc-(R)-2-(7-Octenyl)glycine; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)dec-9-enoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(7-octenyl)-(R)-glycine; (R)-N-Fmoc-2-(7-Octenyl)glycine; Fmoc-2-(7-Octenyl)-(R)-Gly-OH; (R)-2-(7-Octen-1-yl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine; N-α-Fmoc-(R)-2-(7-octenyl)glycine
EINECS	Contact for details

Quality Control

Our (R)-n-Fmoc-2-(7'-Octeny)Glycine is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles for pharmaceutical intermediates, and specifications can be aligned with client requirements for research or development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.