Description

(R)-3,3,3-Trifluoro-2-Hydroxy-2-Methyl-Propionic Acid Ethyl Ester is a high-value chiral building block and fluorinated synthon of significant interest in advanced organic synthesis. Its core value lies in the introduction of a trifluoromethylated quaternary stereocenter, a structural motif that is highly sought after for modulating the physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key chiral precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves compound efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of fluorinated monomers and polymers with unique surface properties, chemical resistance, and optical characteristics.
• Process Chemistry & Scale-Up: A critical intermediate in the development of robust and scalable manufacturing routes for complex fluorinated molecules.

Basic Information

Product Name	(R)-3,3,3-Trifluoro-2-Hydroxy-2-Methyl-Propionic Acid Ethyl Ester
CAS No.	1262860-78-5
Molecular Formula	C7H9F3O3
Molecular Weight	198.14 g/mol
Synonyms	(R)-Ethyl 3,3,3-trifluoro-2-hydroxy-2-methylpropionate; (R)-2-Hydroxy-2-methyl-3,3,3-trifluoropropionic acid ethyl ester; (R)-TFMEP; (R)-Trifluoromethyl Ethyl Lactate; Ethyl (R)-α-Hydroxy-α-trifluoromethylpropionate; (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid ethyl ester; (R)-TFL Ester
EINECS	Contact for details

Quality Control

Our (R)-3,3,3-Trifluoro-2-Hydroxy-2-Methyl-Propionic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis (HPLC/GC), to ensure compliance with exacting pharmaceutical and research-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are properly sealed. Keep away from strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.