Description

Sulfadoxine-D3 is a deuterium-labeled analog of the sulfonamide antibiotic sulfadoxine, specifically designed for use as an internal standard in advanced analytical techniques. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolism studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in method development and validation.

Application

• Internal Standard for LC-MS/MS and GC-MS quantification of sulfadoxine in biological matrices (plasma, serum, urine).
• Metabolite tracking and drug metabolism studies (DMPK) to understand the pharmacokinetic profile of sulfadoxine.
• Method development and validation in bioanalytical assays to meet regulatory guidelines (FDA, EMA).
• Quality control and assurance in the manufacturing of sulfadoxine-based pharmaceutical products.
• Use in stable isotope dilution analysis for high-precision measurement in complex samples.
• Research applications in veterinary medicine and antimalarial drug development programs.

Basic Information

Product Name	Sulfadoxine-D3
CAS No.	1262770-70-6
Molecular Formula	C₁₂H₁₁D₃N₄O₄S
Molecular Weight	313.35 g/mol
Synonyms	4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide-d3; Sulfadoxine (phenyl-d3); Sulfadoxine-d3; Deuterated Sulfadoxine; [²H₃]-Sulfadoxine; SDX-d3; Internal Standard for Sulfadoxine
EINECS	Contact for details

Quality Control

Our Sulfadoxine-D3 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical stability, which are paramount for its use as an analytical standard. Each batch is characterized by advanced spectroscopic methods (NMR, MS) and meets stringent purity criteria. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment, chemical purity, and analytical results. We support compliance with GMP and ISO guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.