Description

Mal-?Peg4-?Propargyl CAS NO 1262681-30-0 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group for thiol conjugation and a propargyl group for azide-based click chemistry. This dual functionality is critical for creating stable, site-specific bioconjugates and advanced polymer architectures. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced material science who require precise and efficient coupling strategies.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via cysteine residues.
• PEGylation Reagent: Modification of peptides, proteins, and nanoparticles to enhance solubility, stability, and pharmacokinetic profiles.
• Hydrogel Formation: Crosslinking agent for creating biocompatible 3D networks for drug delivery and tissue engineering scaffolds.
• Surface Functionalization: Immobilization of biomolecules onto azide-modified surfaces for biosensor and microarray applications.
• Polymer Synthesis: Building block for synthesizing functionalized, multi-arm, or block copolymers via sequential click and thiol-ene reactions.
• Diagnostic Probe Conjugation: Linking targeting ligands (e.g., antibodies, peptides) to imaging agents or fluorescent dyes.

Basic Information

Product Name	Mal-?Peg4-?Propargyl
CAS No.	1262681-30-0
Molecular Formula	C20H31NO9
Molecular Weight	429.46 g/mol
Synonyms	Maleimide-PEG4-propargyl; Propargyl-PEG4-maleimide; 3-((2-(2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2,5-dihydro-1H-pyrrole-2,5-dione; m-PEG4-propargyl maleimide; MAL-PEG4-ALK; Bifunctional PEG linker, Maleimide and Alkyne terminated
EINECS	Contact for details

Quality Control

Our Mal-?Peg4-?Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.