Description

Gs967 is a selective and potent small-molecule inhibitor of the late sodium current (INaL), a key target in cardiac electrophysiology research. This compound matters for its role in investigating and potentially treating cardiac arrhythmias, particularly atrial fibrillation, by modulating sodium channel activity. Pharmaceutical researchers, preclinical development teams, and academic institutions focused on cardiovascular disease models are the primary users of this high-purity biochemical.

Application

• Cardiac Electrophysiology Research: Used as a critical tool compound to study the role of late sodium current (INaL) in arrhythmogenesis and cardiac contractility.
• Preclinical Drug Discovery: Serves as a reference standard and pharmacological probe in the development of novel antiarrhythmic agents targeting sodium channels.
• Mechanistic Studies: Employed in vitro and in vivo to elucidate cellular mechanisms underlying atrial fibrillation, heart failure, and other cardiac conditions.
• Safety Pharmacology: Used in assays to assess the cardiac safety profile of new chemical entities by comparing effects on INaL.
• Academic & Institutional Research: A key reagent for university labs and research institutes conducting fundamental research on ion channel function and cardiac biology.

Basic Information

Product Name	Gs967
CAS No.	1262618-39-2
Molecular Formula	C17H16N4O2S
Molecular Weight	340.40 g/mol
Synonyms	Gs-967; Gs 967; 6-[[4-(Trifluoromethoxy)phenyl]methyl]-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridin-3-one; 6-((4-(Trifluoromethoxy)benzyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3(2H)-one; Late Sodium Current Inhibitor Gs967; INaL Inhibitor Gs967
EINECS	Contact for details

Quality Control

Our Gs967 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and batch-specific data is provided with every shipment to guarantee traceability and consistency for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.