Description

trans-3-Fluorocyclobutanol CAS NO 1262278-60-3 is a versatile fluorinated cyclobutane derivative, a key chiral building block prized for its unique three-dimensional structure and the electronic properties imparted by the fluorine atom. This compound is critical for medicinal chemistry and advanced materials research, where it serves as a sophisticated synthon for introducing conformational rigidity and modulating physicochemical properties. It is primarily sought after by pharmaceutical R&D teams and specialty chemical manufacturers developing novel active ingredients, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel drug candidates, particularly in kinase inhibitors and CNS-targeting molecules.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and pesticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Incorporated into the design of specialty polymers and liquid crystals to fine-tune thermal stability and optical properties.
• Fluorine Chemistry Studies: A valuable reference compound for investigating the stereoelectronic effects of fluorine in constrained alicyclic systems.
• Peptidomimetics: Used to construct conformationally restricted amino acid analogs for probing protein-ligand interactions.

Basic Information

Product Name	trans-3-Fluorocyclobutanol
CAS No.	1262278-60-3
Molecular Formula	C4H7FO
Molecular Weight	90.10 g/mol
Synonyms	(1r,3r)-3-Fluorocyclobutanol; trans-3-Fluorocyclobutan-1-ol; (R,R)-3-Fluorocyclobutanol; 3-Fluorocyclobutanol (trans-); 3-Fluoro-1-cyclobutanol; FCB-OH; Fluorocyclobutanol; 1262278-60-3
EINECS	Contact for details

Quality Control

Our trans-3-Fluorocyclobutanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.