Description

Tazarotene Sulfone is a high-purity pharmaceutical intermediate and reference standard of significant importance in advanced research and development. Its primary value lies in its role as a key metabolite and degradation product of Tazarotene, a topical retinoid used to treat psoriasis and acne. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on dermatological drug development, analytical method validation, and quality control processes for retinoid-based therapies.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification and quantification of Tazarotene and its related substances in drug products and raw materials.
• Metabolite Studies: Critical for pharmacokinetic and metabolic pathway research of Tazarotene in preclinical and clinical studies.
• Impurity Profiling: Employed in the development and validation of analytical methods (HPLC, LC-MS) to monitor and control degradation products in active pharmaceutical ingredient (API) batches.
• Process Chemistry Research: Serves as an intermediate or marker in the synthesis and scale-up optimization of Tazarotene production.
• Dermatological R&D: Used in investigative studies to understand the activity, stability, and formulation of retinoid compounds.
• Quality Assurance/Control: An essential component for establishing specification limits and ensuring compliance with ICH guidelines for impurities in new drug applications.

Basic Information

Product Name	Tazarotene Sulfone
CAS No.	1262228-27-2
Molecular Formula	C₂₁H₂₁NO₃S
Molecular Weight	367.46 g/mol
Synonyms	Ethyl 6-[(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinate S,S-dioxide; Tazarotene Sulfoxide; AGN 190299 Sulfone; AGN-190299 Sulfone; Tazarotenic Acid Sulfone; Zorac Metabolite; Retinoid AGN 190299 Sulfone
EINECS	Contact for details

Quality Control

Our Tazarotene Sulfone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical reference standards and advanced intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider conditions under an inert atmosphere to prevent oxidation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.