Description

Rifampicin-D3 CAS NO 1262052-36-7 is a deuterium-labeled isotopologue of the broad-spectrum antibiotic rifampicin, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is an essential tool for quantitative mass spectrometry, enabling precise pharmacokinetic and metabolic studies without isotopic interference. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug metabolism and disposition (DMPK) research, bioanalytical method development, and clinical trial support.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical quantitative reference standard in bioanalytical assays for rifampicin in plasma, serum, and tissue samples.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track and quantify the parent drug and its metabolites.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Enables accurate measurement of rifampicin concentrations in patient samples to optimize dosing regimens, particularly in tuberculosis treatment.
• Method Development and Validation: Essential for developing and validating robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision quantification techniques to achieve superior accuracy and minimize matrix effects.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological matrices.

Basic Information

Product Name	Rifampicin-D3
CAS No.	1262052-36-7
Molecular Formula	C43H55D3N4O12
Molecular Weight	826.00 g/mol (approx.)
Synonyms	Rifampicin-d3; (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-Pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-[(4-methylpiperazin-1-yl)imino]methyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate-d3; Rifampin-d3; 3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV-d3; Rifadin-d3; Rimactane-d3; Deuterated Rifampicin
EINECS	Contact for details

Quality Control

Our Rifampicin-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic methods (NMR, HRMS) and analyzed via HPLC to confirm identity, purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) is provided, detailing assay (by HPLC), chemical purity, isotopic purity (D-enrichment), and residual solvent content, supporting compliance with relevant research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Reddish-brown to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.