Description

2-(Di-T-Butylphosphino)-3-Methoxy-6-Methyl-2',4',6'-Tri-I-Propyl-1,1'-Biphenyl is a sophisticated, sterically hindered monodentate phosphine ligand, a key component in modern catalytic chemistry. Its primary value lies in enabling highly efficient and selective cross-coupling reactions, which are fundamental for constructing complex organic molecules. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require robust and reliable catalysts for challenging synthetic transformations.

Application

• As a premier ligand in palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura, Buchwald-Hartwig amination, and Negishi couplings.
• Enabling the synthesis of active pharmaceutical ingredients (APIs) and complex drug intermediates under mild conditions.
• Facilitating the production of agrochemicals and fine chemicals requiring high selectivity and yield.
• Used in the development of advanced materials, such as organic semiconductors and polymers.
• Critical for academic and industrial R&D in methodology development and catalyst optimization.
• Supporting process chemistry scale-up for more sustainable and cost-effective manufacturing routes.

Basic Information

Product Name	2-(Di-T-Butylphosphino)-3-Methoxy-6-Methyl-2',4',6'-Tri-I-Propyl-1,1'-Biphenyl
CAS No.	1262046-34-3
Molecular Formula	C32H49OP
Molecular Weight	480.71 g/mol
Synonyms	2-(Di-tert-Butylphosphino)-3-methoxy-6-methyl-2',4',6'-triisopropyl-1,1'-biphenyl; tBuBrettPhos; BrettPhos Precursor; RuPhos Precursor Ligand; CPhos Precursor; 2-(Di-tert-butylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl derivative; Monodentate Biarylphosphine Ligand; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 2-(Di-T-Butylphosphino)-3-Methoxy-6-Methyl-2',4',6'-Tri-I-Propyl-1,1'-Biphenyl adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including NMR (1H, 13C, 31P) and HPLC to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should only be opened in an inert environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR Purity	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.