Description

Benzonitrile, 3-Amino-5-(Trifluoromethoxy)- is a high-value, multi-functional aromatic nitrile building block distinguished by its amino and trifluoromethoxy substituents. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, offering a unique combination of electronic and steric properties for molecular design. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a critical building block for developing new-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances bioavailability and metabolic stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs) due to its coordinating nitrile and amino groups.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and electronic materials where its aromatic core and functional groups impart specific properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Benzonitrile, 3-Amino-5-(Trifluoromethoxy)-
CAS No.	1261873-36-2
Molecular Formula	C8H5F3N2O
Molecular Weight	202.13 g/mol
Synonyms	3-Amino-5-(trifluoromethoxy)benzonitrile; 5-Cyano-3-(trifluoromethoxy)aniline; 3-Amino-5-(trifluoromethoxy)phenyl cyanide; 3-Cyano-5-(trifluoromethoxy)aniline; [3-Amino-5-(trifluoromethoxy)phenyl]acetonitrile derivative (precursor); Benzonitrile, amino(trifluoromethoxy)-; AATF (abbrev.); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-5-(Trifluoromethoxy)benzonitrile is produced under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.