Description

Benzonitrile, 5-Bromo-2-(Difluoromethoxy)- is a high-value, multi-functional aromatic nitrile derivative, distinguished by its bromo and difluoromethoxy substituents. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry, enabling the development of novel active ingredients. It is primarily required by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical sectors for creating complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a valuable starting material for creating novel ligands and catalysts used in cross-coupling reactions and other transition metal-catalyzed processes.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties imparted by the halogen and fluorine atoms.
• Chemical Biology & Proteomics: Acts as a versatile scaffold for designing chemical probes and activity-based protein profiling (ABPP) agents to study enzyme function.

Basic Information

Product Name	Benzonitrile, 5-Bromo-2-(Difluoromethoxy)-
CAS No.	1261859-60-2
Molecular Formula	C8H4BrF2NO
Molecular Weight	248.03 g/mol
Synonyms	5-Bromo-2-(difluoromethoxy)benzonitrile; 2-(Difluoromethoxy)-5-bromobenzonitrile; 5-Bromo-2-(difluoromethoxy)phenyl cyanide; Benzonitrile, 5-bromo-2-(difluoromethoxy)-; 1261859-60-2; 5-Bromo-2-difluoromethoxybenzonitrile
EINECS	Contact for details

Quality Control

Our production of Benzonitrile, 5-Bromo-2-(Difluoromethoxy)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Every lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 98.0% / ≥ 99.0% (High Purity Grades)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.