Description

4-(Difluoromethoxy)-3-Fluorophenylacetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its unique molecular architecture, which incorporates both difluoromethoxy and fluorophenylacetic acid functionalities, enabling precise modulation of physicochemical properties in target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its fluorine atoms are critical for enhancing metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and metabolic conditions.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine motifs contribute to improved pest selectivity and environmental persistence profiles.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Organic Electronics: Employed in the development of novel organic semiconductors and electron-transport materials due to its ability to fine-tune electronic properties.
• Chemical Research & Development: A versatile building block for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and route scouting.
• Fluorine Chemistry Reference Standard: Used as a pure standard in analytical laboratories for method development and validation in fluorine-specific detection techniques.

Basic Information

Product Name	4-(Difluoromethoxy)-3-Fluorophenylacetic Acid
CAS No.	1261851-55-1
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	3-Fluoro-4-(difluoromethoxy)phenylacetic acid; [4-(Difluoromethoxy)-3-fluorophenyl]acetic acid; 2-[3-Fluoro-4-(difluoromethoxy)phenyl]acetic acid; 4-(Difluoromethoxy)-3-fluorobenzeneacetic acid; α-(4-(Difluoromethoxy)-3-fluorophenyl)acetic acid; DFM-F-PAA; CAS 1261851-55-1
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-3-Fluorophenylacetic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.