Description

1-(Difluoromethoxy)-4-Fluoro-2-Iodobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring iodine, fluorine, and a difluoromethoxy group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoromethoxy and fluoro groups can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine moiety acts as an excellent handle for versatile palladium-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Heck reactions, to form new carbon-carbon bonds.
• Fluorine Chemistry Research: An important substrate for studying the effects of multiple fluorine atoms on molecular conformation, lipophilicity, and biological activity in medicinal chemistry.
• Labeling and Tracer Development: Potential use in developing compounds for positron emission tomography (PET) imaging, leveraging the iodine for further radioiodination.

Basic Information

Product Name	1-(Difluoromethoxy)-4-Fluoro-2-Iodobenzene
CAS No.	1261827-29-5
Molecular Formula	C7H4F3IO
Molecular Weight	295.01 g/mol
Synonyms	4-Fluoro-2-iodo-1-(difluoromethoxy)benzene; 2-Iodo-4-fluoro-1-(difluoromethoxy)benzene; 1-(Difluoromethoxy)-4-fluoro-2-iodobenzene; Benzene, 1-(difluoromethoxy)-4-fluoro-2-iodo-; 4-Fluoro-2-iodophenyl difluoromethyl ether; DFIFB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-4-Fluoro-2-Iodobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to cGMP principles and regulatory compliance (REACH, TSCA) ensures a reliable supply for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.