Description

1-(Difluoromethoxy)-3-Iodo-2-Methylbenzene is a high-purity, multi-functional halogenated aromatic building block. This compound is valued for its unique difluoromethoxy and iodo substituents, which are critical for introducing specific steric and electronic properties into target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring halogenated aromatic cores.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Research: Essential for studying the effects of fluorine substitution in organic molecules, aiding in the design of compounds with improved lipophilicity and bioavailability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram quantities.

Basic Information

Item	Detail
Product Name	1-(Difluoromethoxy)-3-Iodo-2-Methylbenzene
CAS No.	1261825-62-0
Molecular Formula	C8H7F2IO
Molecular Weight	284.05 g/mol
Synonyms	3-Iodo-2-methyl-1-(difluoromethoxy)benzene; 2-Methyl-3-iodo-α,α-difluoroanisole; 1-Iodo-2-(difluoromethoxy)-3-methylbenzene; Benzene, 1-(difluoromethoxy)-3-iodo-2-methyl-; Difluoromethoxy-iodo-methylbenzene; DFIMB (abbrev.)
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-3-Iodo-2-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.