Description

3-Chloro-5-(Trifluoromethoxy)Anisole is a high-purity, multi-functional aromatic ether building block designed for advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethoxy substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical sectors seeking to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials, contributing to the molecular framework of display and lighting components.
• Organic Synthesis Reagent: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, functionalized aromatics.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating specialized chemical libraries.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethoxy)Anisole
CAS No.	1261822-54-1
Molecular Formula	C8H6ClF3O2
Molecular Weight	226.58 g/mol
Synonyms	1-Chloro-3-methoxy-5-(trifluoromethoxy)benzene; 3-Chloro-5-(trifluoromethoxy)methoxybenzene; 3-Chloro-5-(trifluoromethoxy)phenyl methyl ether; Anisole, 3-chloro-5-(trifluoromethoxy)-; Benzene, 1-chloro-3-methoxy-5-(trifluoromethoxy)-; Methyl 3-chloro-5-(trifluoromethoxy)phenyl ether
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-(Trifluoromethoxy)Anisole is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard quality commitment includes comprehensive identity confirmation, purity assay, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.