Description

3-(3-Bromo-2-Fluorophenyl)Propanoic Acid is a high-purity fluorinated and brominated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique halogenated phenylpropanoic acid structure, which serves as a versatile intermediate in the development of complex molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the fluorine and bromine substituents can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for fluorinated aromatic components in electronic and display materials.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Stille couplings to construct biaryl systems.
• Medicinal Chemistry SAR Studies: Employed in structure-activity relationship (SAR) explorations to fine-tune the potency and pharmacokinetic properties of drug candidates.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific halogenated aromatic architectures.

Basic Information

Product Name	3-(3-Bromo-2-Fluorophenyl)Propanoic Acid
CAS No.	1261814-91-8
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	3-(3-Bromo-2-fluorophenyl)propionic acid; 3-Bromo-2-fluorophenylpropanoic acid; 2-Fluoro-3-bromohydrocinnamic acid; 3-(3-Br-2-F-C6H3)CH2CH2COOH; β-(3-Bromo-2-fluorophenyl)propanoic acid; NSC 1261814-91-8; 1261814-91-8
EINECS	Contact for details

Quality Control

Every batch of 3-(3-Bromo-2-Fluorophenyl)Propanoic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.