Description

2-Bromo-4-Iodobenzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromine and iodine substituents, makes it a critical intermediate for constructing complex molecules through selective cross-coupling reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen atoms for structural diversification.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi couplings, where the iodine and bromine atoms offer orthogonal reactivity for sequential functionalization.
• Ligand and Catalyst Development: Employed in the preparation of novel phosphine or N-heterocyclic carbene (NHC) ligands for transition metal catalysis.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or photoaffinity labels for proteomics and biomarker discovery research.

Basic Information

Item	Detail
Product Name	2-Bromo-4-Iodobenzonitrile
CAS No.	1261776-03-7
Molecular Formula	C7H3BrIN
Molecular Weight	307.92 g/mol
Synonyms	4-Iodo-2-bromobenzonitrile; 2-Bromo-4-iodobenzonitrile; Benzonitrile, 2-bromo-4-iodo-; 2-Bromo-4-iodo-benzonitrile; 2-Bromo-4-iodobenzocarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Iodobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Solubility	Soluble in common organic solvents (DMF, THF, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.